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Dott.ssa Elena Grassi

  • Dottorato: 28° ciclo
  • Matricola: 238338

Attività di ricerca

 Computational studies of gene regulation based on next-generation sequencing - Evolution of gene expression

  • Marnetto D, Molineris I, Grassi E,  Provero P. Genome-wide identification and characterization of fixed human-specific regulatory regions,  Am J Hum Genet. 2014 Jul 3;95(1):39-48. doi: 10.1016/j.ajhg.2014.05.011. PubMed PMID: 24995867; PubMed Central PMCID: PMC4085640.

  • Grassi E, Di Gregorio F, Molineris I. KungFQ: a simple and powerful approach to compress fastq files, IEEE/ACM Trans Comput Biol Bioinform, 2012 Nov-Dec;9(6):1837-42. doi: 10.1109/TCBB.2012.123. PubMed PMID: 23221092.

  • Molineris I, Grassi E, Ala U, Di Cunto F, Provero P. Evolution of promoter affinity for transcription factors in the human lineage. Mol Biol Evol. 2011 Aug;28(8):2173-83. doi: 10.1093/molbev/msr027. Epub 2011 Feb 18. PubMed PMID:21335606.

  • Piro RM, Ala U, Molineris I, Grassi E, Bracco C, Perego GP, Provero P, Di Cunto F. An atlas of tissue-specific conserved coexpression for functional annotation and disease gene prediction. Eur J Hum Genet. 2011 Nov;19(11):1173-80. doi: 10.1038/ejhg.2011.96. Epub 2011 Jun 8. PubMed PMID: 21654723; PubMed Central PMCID: PMC3198151.

  • Ala U, Piro RM, Grassi E, Damasco C, Silengo L, Oti M, Provero P, Di Cunto F. Prediction of human disease genes by human-mouse conserved coexpression analysis. PLoS Comput Biol. 2008 Mar 28;4(3):e1000043. doi: 10.1371/journal.pcbi.1000043. PubMed PMID: 18369433; PubMed Central PMCID: PMC2268251.

  • Penna E, Orso F, Cimino D, Vercellino I, Grassi E, Quaglino E, Turco E, Taverna D. miR-214 coordinates melanoma progression by upregulating ALCAM through TFAP2 and miR-148b downmodulation. Cancer Res. 2013 Jul 1;73(13):4098-111. doi: 10.1158/0008-5472.CAN-12-3686. Epub 2013 May 10. PubMed PMID: 23667173. 

  • M. Coppo, F. Damiani, M. Drocco, E. Grassi, E. Sciacca,S. Spinella, A. Troina, 2012, “Simulation techniques for the calculus of wrapped compartments”, Theoretical Computer Science

  • M. Coppo, F. Damiani, M. Drocco, E. Grassi, M. Guether, A. Troina Modelling Ammonium Transporters in Arbuscular Mycorrhiza Symbiosis”, 2011, Transactions on Computational Systems Biology

Poster e software demo

  • “A comprehensive transcriptome analysis of GABA-differentiating neural stem cells aimed at dissecting molecular mechanisms underlying cell cycle exit, neuronal commitment and differentiation”, E. Grassi , U. Ala, A. Lembo, R. Santoro, F. Di Cunto, P. Provero, F. Neri, D. Incarnato, S. Oliviero, L. Conti, G.R. Merlo, al convegno ”Stem Cells, Development and Regenerative Medicine”, Giugno 2014
  •  “Roar: detecting alternative sequencing libraries”: software demo al “NETTAB & IB 2015, Joint NETTAB and Integrative Bioinformatics Meetings”

  • “Stem Cells, Development and Regenerative Medicine”,  Salerno, 6-7 Giugno 2014
  • “European Bioconductor Developers’ Meeting”, Heidelberg 12-13/01/2015

  • “NETTAB & IB 2015, Joint NETTAB and Integrative Bioinformatics
    Meetings”, Bari 14-16/10/2015

  • “The Polycomb protein BMI1 promotes the metastatic switch in melanoma”,
    Roberta Ferretti, 17/12/2014, ospite Mara Brancaccio

  • Seminari organizzati dal dottorato in Sistemi complessi, tenuti il 05/02/1015:
    1. “Classification with many variables and imbalanced data: (many)
    problems and (few) solutions”, Dr. Lara Lusa
    2. “Next generation diagnostic and clinics”, Prof. Massimo Delledonne
    3. “Charting and deciphering epigenomic landscapes”, Dr. Mattia Peli-
    zola
    4. “DNA methylation and demethylation in embryonic stem cells”, Francesco
    Neri

  • “Circular and linear Non-Coding RNAs in tumorigenesis”, Prof. Pier
    Paolo Pandolfi, 06/05/2015

  • “Italian and Silk Road genetic isolates to dissect complex and quantitative
    trait”, Prof. Paolo Gasparini, 19/05/2015, ospite Giuseppe Matullo

  • “Lo Stato dell’Arte della Medicina/Chirurgia Rigenerativa e Prospettive
    Future. Il Futuro `e gi`a qui?”, Prof. Mario Marazzi, 9/7/2015, ospite
    Vincenzo Calautti

  • “First Workshop of the Center for Complexity Biosystems”, Milano,
    21/9/2015, 10 seminars from the Center members and hosts
    (http://complexitybiosystems.it/en/events/first-workshop-of-cc-and-b).

Biostatistics, Introduzione alla Ricerca Bibliografica, Inglese Scientifico

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