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Dott.ssa Marilena Marraudino

Contatti

Tutore

Prof. Giancarlo Panzica

Curriculum vitae

Curriculum Vitae

Tesi di dottorato

Kisspeptin innervation of the Hypothalamic Paraventricular Nucleus: key for reproductive and metabolic control. Effects of postnatal exposure to Genistein.

 

Attività di ricerca

Kisspeptin innervation of the Hypothalamic Paraventricular Nucleus: key for reproductive and metabolic control. Effects of postnatal exposure to Genistein.

The energy homeostasis of the organism is very important for both the regular course of puberty and for fertility. Several studies have suggested a relationships among kisspeptin system and neural circuits controlling food intake and energy metabolism. The most important center for the regulation of these two physiological activities is the hypothalamic paraventricular nucleus (PVN). The kisspeptin system is clustered in two main groups of cell bodies (in anterior ventral periventricular region and in arcuate nucleus) that send fibres mainly at the GnRH neurons and in a few other locations, including the PVN. I want to study if Endocrine Disrupting Chemical (EDCs) may interact with the kisspeptin-PVN system. Several EDCs are estrogen-like and/or anti-androgenic compounds that disrupt and interfere with the production, release, transport, metabolism, binding and elimination of natural hormones in the body, especially with those responsible for the maintenance of homeostasis and the regulation of developmental processes. I would therefore focus on possible mechanisms associated with the effects of EDCs on homeostasis control, food intake and energy store. In fact, many studies show that some EDCs can act as 'obesogens' and increase the risk of developing metabolic disorders such as diabetes and obesity. These compounds increase body weight in mammals and disturb levels of key hormones linked to energy homeostasis, at the moment their involvement in disregulation of neural circuits controlling food intake and energy metabolism has demonstrated in a few studies.

Data report - XXVIII ciclo, 25-26.02.2014

Corso di Neuroimaging funzionale, Ospedale Koelliker, Turin, 14-18.07.2014

Introduzione alla ricerca bibliografica, Turin, 17 e 24.09.2014

Allen Institute for Brain Science-Informational overwiev and training workshop, Terry Gilbert PhD, Turin, 03.10.2014

Data report - XXIX ciclo, 24-25.02.2015

Corso di Biostatistica, Turin, 15 e 23.06.2015 - 13.07.2015

Neurobiology I. Cellular and molecular organization of the nervous system, Turin, 06-07.2015

D-Day 2015, Turin, 16.09.2015

International PhD Course on The Aging Brain: Cellular Mechanism Interfacing Human Pathology, Turin, 28.09-02.10.2015

D-Day 2016, Turin, 15.09.2016

Giornata dedicate alla valorizzazione delle competenze dei dottori di ricerca e al postdoc, Turin, 04.10.2016

Workshop 'Essential Public Speaking Skills for postdocs', Turin, 04.10.2016

D-Day 2017, Turin, 19.09.2017

 

 

E. Bo, A. Farinetti, M. Marraudino, D. Sterchele, C. Eva, S. Gotti and G. Panzica. Adult exposure to tributyltin affects hypothalamic neuropeptide Y, Y1 receptor distribution, and circulating leptin in mice. Andrology. 2016 Jul;4(4):723-34. (doi: 10.1111/andr.12222)

G. Ponti, A. Rodriguez-Gomez, A. Farinetti, M. Marraudino, F. Filice, B. Foglio, G. Sciacca, G.C.Panzica, S.Gotti. Early postnatal genistein administration permanently affects nitrergic and vasopressinergic systems in a sex-specific way. Neuroscience. 2017 Mar 27;346:203-215. (doi:10.1016/j.neuroscience.2017.01.024)

M. Marraudino, D. Miceli, A. Farinetti, G.C. Panzica and S. Gotti. The Kisspeptin Innervation of the Hypothalamic Paraventricular Nucleus: Sexual Dimorphism and Effect of Estrous Cycle in Female Mice. J. Anatomy. 2017 Jun;230(6):775-786. (doi:10.1111/joa.12603)

L. Oboti, S. Trova, R. Schellino, M. Marraudino, N.R Harris, O.M Abiona, M. Stampar, W. Lin, P.Peretto.  Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Puberty. Frontiers Neuroanatomy. 2017 May 23;11:44. (doi: 10.3389/fnana.2017.00044)

 A.Farinetti, M. Marraudino, G. Ponti, G.C.Panzica, S.Gotti. Chronic treatment with tributyltin induces sexually dimorphic alterations of POMC system and activated leptin receptor in the hypothalamic Arcuate nucleus of adult mice. (Submitted to Journal of Neuroendocrinology).

M. Marraudino, A. Farinetti, D. Miceli, S. Gotti, G.C. Panzica (2014) Kisspeptin and food intake: neuroendocrine relatioships at the level of the hypothalamic paraventricular nucleus. XXIV Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), BOLOGNA, Italy, November 28/29, 2014. European journal of histochemistry a journal of functional cytology, volume 58/supplement 2, ISSN 1121-760X, 2014.

M. Marraudino, A. Farinetti, D. Miceli, S. Gotti, G.C. Panzica (2015) Kisspeptin and food intake: neuroendocrine relatioships at the level of the hypothalamic paraventricular nucleus. VIII International Meeting STEROIDS AND NERVOUS SYSTEM, ORBASSANO (TO), Italy, February 14/18, 2015.

G. Ponti, A. Rodriguez-Gomez, A. Farinetti, M. Marraudino, F. Filice, B. Foglio, GC. Panzica, S. Gotti (2015) Hypothalamic circuits controlling anxiety are affected in a sex dimorphic way by early postnatal Genistein administration: analysis of Nos system in the amygdala and the paraventricular nucleus. VIII International Meeting STEROIDS AND NERVOUS SYSTEM, ORBASSANO (TO), Italy, February 14/18, 2015.

G.C Panzica, E. Bo, M. Marraudino, A. Farinetti, S. Gotti (2015) Impact of endocrine distrupters on neuroendocrine circuits controlling food intake. VIII Copenhagen Workshop on Endocrine Disrupters, COPENHAGEN, Denmark, April 27/30, 2015.

M. Marraudino, D. Miceli, A. Farinetti, S. Gotti, G.C Panzica (2015) Kisspeptin and food intake: neuroendocrine relationships at the level of the hypothalamic paraventricular nucleus. COST Action BM 1105, Joint Scientific Meeting & Training School, Monash University PRATO Center, Italy, April 27/29, 2015.

G. Ponti, A. Rodriguez-Gomez, A. Farinetti, M. Marraudino, F. Filice, B. Foglio, GC. Panzica, S. Gotti (2015) You are what you ate: long term effects of phitoestrogens exposure in early postnatal life. LXIX Convegno SISVet, University of Perugia, Italy, June 15/17, 2015.

M. Marraudino, A. Farinetti, E. Troisi, D. Miceli, S. Gotti, G.C. Panzica (2015) Kisspeptin and Paraventricular Nucleus: effects of bisphenol A on CD1 female mice. XXV Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), Rome, Italy, November 27/28, 2015.

E. Carlini, M. Marraudino, Jeremic M., Di Lorenzo D., G.C. Panzica, S. Gotti (2015) Effects of treatment with environmental endocrine disruptors on hypothalamic POMC expression. XXV Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), Rome, Italy, November 27/28, 2015.

G. Ponti, A. Rodriguez-Gomez, A. Farinetti, M. Marraudino, F. Filice, B. Foglio, G. Sciacca, G.C  Panzica, S. Gotti. Sex specific permanent effect of early postnatal genistein administration on nitrergic and vasopressinergic systems. 10th FENS, Forum of Neuroscience, Copenhagen, Denmark, July 2/6, 2016.

G. Ponti, A. Rodriguez-Gomez, A. Farinetti, M. Marraudino, F. Filice, B. Foglio, G. Sciacca, G.C  Panzica, S. Gotti. Early administration of the phytoestrogen genistein induces sex specific permanent alterations of nitrinergic and vasopressinergic systems.70° Congresso Nazionale Società Italiana di Anatomia ed Istologia (SIAI), Rome, Italy, 15/17 September, 2016.

M. Marraudino, G. Ponti, A. Farinetti, E. Macchi, S. Gotti, M. Keller, G.C. Panzica. Sexually dimorphic effects of early postnatal genistein administration on kisspeptin system. Neuroscience 2016 - Society for Neuroscience, San Diego, California (USA), November 12/16, 2016.

 M. Marraudino, G. Ponti, A. Farinetti, S. Gotti, M. Keller, P. Collado, G.C. Panzica. The sexually dimorphic obesogenic effect of early postnatal genistein administration on CD1 mice. XXVI Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), Verona, Italy, November 24/25, 2016.

 A. Farinetti, M. Marraudino, G. Ponti, S. Gotti, G.C. Panzica. Sexually dimorphic effect of chronic treatment with tributyltin on brain circuits involved in the food intake behavior in adult mice. XXVI Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), Verona, Italy, November 24/25, 2016.

 A. Farinetti, A. Rodriguez-Gomez, G. Grippaldi, M. Marraudino, S. Gotti, GC. Panzica, G. Ponti. Permanent effects of early postnatal genistein administration on th positive catecholaminergic neurons in mouse. XXVI Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), Verona, Italy, November 24/25, 2016.

M. Marraudino, G.C. Panzica, S. Gotti, M.A. Arévalo, L.M. Garcia-Segura. Sex dimorphic effect of genistein on hypothalamic neuronal differentiation in vitro. IX International Meeting Steroids and Nervous System, Turin, Italy, February 11/15, 2017.

M. Marraudino,  A. Farinett, E. Macchi, P.  Accornero, G. Grippaldi, S. Gotti, GC. Panzica, G. Ponti. Impaired fertility features in mice treated with soy phytoestrogens during neonatal development. Babies and Animals: pediatrician meet vets, Turin, Italy, April 21/22, 2017

M. Marraudino, G. Ponti, A. Farinett, E. Macchi, P.  Accornero, S. Gotti, P. Collado, M. Keller, GC. Panzica. Early postnatal genistein administration has a sexually dimorphic obesogenic effect and organizational effects on hypothalamic neuroendocrine circuits in CD1 mice. II International Congress of Psychobiology, Avila, Spain, July 19/21, 2017.

M. Marraudino, G. Ponti, A. Farinett, E. Macchi, P.  Accornero, S. Gotti, P. Collado, M. Keller, GC. Panzica. Early postnatal genistein administration has a sexually dimorphic obesogenic effect and organizational effects on hypothalamic neuroendocrine circuits in CD1 mice. D-Day 2017, Turin, Italy, September 19, 2017.

M. Marraudino, G. Ponti, A. Farinett, E. Macchi, P.  Accornero, S. Gotti, P. Collado, M. Keller, GC. Panzica. The sexually dimorphic obesogenic effect of early postnatal genistein administration on CD1 mice. XVII Società italiana Neuroscienze (SINS) National Congress, Lacco Ameno, Ischia, Italy, October 1/4, 2017.

 

 

XXIV Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), BOLOGNA, Italy, November 28/29, 2014.

VIII International Meeting STEROIDS AND NERVOUS SYSTEM, Orbassano (TO), Italy, February 14/18, 2015.

COST Action BM 1105, Joint Scientific Meeting & Training School, Monash University PRATO Center, Italy, April 27/29, 2015.

XXV Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.SN.), Rome, Italy, November 27/28, 2015.

Neuroscience 2016 - Society for Neuroscience, San Diego, California (USA), November 12/16 , 2016.

XXVI Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), Rome, Italy, November 24/25,  2016.

IX International Meeting STEROIDS AND NERVOUS SYSTEM, Turin, Italy, February 11/15, 2017.

II International Congress of Psychobiology, Avila, Spain, July 19/21, 2017.

XVII Società italiana Neuroscienze (SINS) National Congress, Lacco Ameno, Ischia, Italy, October 1/4, 2017.

 

M. Marraudino, A. Farinetti, D. Miceli, S. Gotti, G.C. Panzica (2014) Kisspeptin and food intake: neuroendocrine relatioships at the level of the hypothalamic paraventricular nucleus. XXIV Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), BOLOGNA, Italy, November 28/29, 2014.

 M. Marraudino, D. Miceli, A. Farinetti, S. Gotti, G.C Panzica (2015) Kisspeptin and food intake: neuroendocrine relationships at the level of the hypothalamic paraventricular nucleus. COST Action BM 1105, Joint Scientific Meeting & Training School, Monash University PRATO Center, Italy, April 27/29, 2015.

M. Marraudino, A. Farinetti, E. Troisi, D. Miceli, S. Gotti, G.C. Panzica (2015) Kisspeptin and Paraventricular Nucleus: effects of bisphenol A on CD1 female mice. XXV Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), Rome, Italy, November 27/28, 2015.

M. Marraudino, G. Ponti, A. Farinetti, S. Gotti, M. Keller, P. Collado, G.C. Panzica. The sexually dimorphic obesogenic effect of early postnatal genistein administration on CD1 mice. XXVI Convegno Nazionale del Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), Verona, Italy, November 24/25, 2016.

M. Marraudino, G. Ponti, A. Farinetti,  E. Macchi, S. Gotti, M. Keller, P. Collado, G.C. Panzica. The sexually dimorphic obesogenic effect of early postnatal genistein administration on CD1 mice. IX International Meeting STEROIDS AND NERVOUS SYSTEM, Turin, Italy, February 11/15, 2017.

 

2014 - Grant EDISU Piemonte (PhD, University of Turin)
2014 - Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), travel grant.
2015 - Cost Action GNRH Network (STSMs - Short term Scientific Missions in Tours, France)
2015 - Cost Action GNRH Network (Training school- Prato), travel grant.
2015/2016 - Grant Erasmus+ (Madrid, Spain)
2016 - Cost Action GNRH Network (STSMs - Short term Scientific Missions in Madrid, Spain)

2017 - Price awarded for best poster presentation at 'Babies and Animals: pediatrician meet vets', Turin, Italy, April 21/22.
2017 - Società italiana Neuroscienze (SINS) National Congress, travel grant.

 

2014

'Mechanisms of cortical plasticity: from the visual to the motor cortex' Matteo Caleo, Istituto di Neuroscienze, CNR, Pisa. NICO, 04.04.2014

'Pluripotent stem cells as a model of in vitro neurogenesis' Federico Cremisi, Ricercatore della Classe di Scienze, Scuola Normale Superiore di Pisa. NICO, 30.05.2014

'The role of thalamic imputs in the development of the prefrontal cortex and its relevance in schizofrenia' Zakaria Ouaz, dottorando Università Cadi Ayyad di Marrakech. NICO, 04.06.2014

'Nanotools for Neuroscience' Carlo Ricciardi, Emiliano Descrovi, Fabrizio Pirri, DISAT-Politecnico di Torino. NICO, 12.06.2014

'Etica e ricerca: questioni morali relative all'uso di materiale umano' Maurizio Balistreri, Dip. Filosofia e Scienza dell'Educazione, Università di Torino. NICO, 19.06.2014

'FENS Young investigator'. NICO, 30.06.2014

'Essere giovani protagonisti in H2020: il CV e opportunità di finanziamento attraverso la mobilità internazionale' Carmen Fiore e Claudia Barale. CSTF, 02.07.2014

'Transcriptional factor EB and the development of cardiovascular system' Federico Bussolino, Università di Torino. NICO, Torino, 27.07. 2014

'Leuko-vascular interaction as a new player in neuromodulation: inside from experimental epilepsy', Paolo Fabene, Università di Verona. NICO, Torino, 17.10.2014

'Enriched the environment to empower the brain: towards an endogenous pharmacoterapy' Alessandro Sale, Università di Pisa. NICO, Torino, 03.11. 2014

'An update on neuroactive steroids' Roberto Cosimo Melcangi, Università di Milano. NICO, Torino, 11.11. 2014

'Resting state functiona connectivity: una finestra sul funzionamento a riposo del cervello' Franco Cauda, Università di Torino. NICO, Torino, 05.12. 2014

2015

'Cytoskeletal Mechanisms of axon growth and Regeneration' Frank Bradke, Università di Bonn. NICO, Torino, 09.02. 2015

'Mapping neuronal inputs into kiss1 neurons in the mouse' Bill Colledge, Università di Cambridge. INRA, Tours, 13.05.2015

'Glio-trasmettitori nel sistema nevoso periferico' Valerio Magnaghi, Università di Milano. NICO, Torino, 10.07.2015

'Class 3 semaphorins in the control of GnRH neuron development and diseases' Anna Cariboni, Università di Milano. NICO, Torino, 23.10.2015

2016

'Monitoring Food Intake, Water Intake and Ingestive Behavior In Group-Housed Rodents'  Mads Kjolby and Niels Wellner, Aarhus University Department of Biomedicine, Denmark. Webinar, 22.09.2016

'NGF and neuro-behavioural plasticity: coping with stress in mice, rats and parachutists' Enrico Alleva, Istituto Superiore di Sanità, Roma. NICO, Torino, 18.10.2016

2017

'How stem cells signal to host immune' -Stefano Pluchino, University of Cambridge. NICO, Torino. 16.03.2017

'Tumor immunoescape during glioma progression' Irene Appolloni, Laboratory of Gene Transfer - IRCCS AOU S. Martino-IST, Genova. NICO, Torino. 08.09.2017

 

March 16, 2015 - June 3, 2015: INRA, Neuroendocrinologie des Interactions et Comportements Sexuels (NICS), Matthieu Keller. Tours, France.

January 15, 2016 - July 15, 2016: Cajal Institute, Neuroactive steroids, Luis Miguel Garcia-Segura. Madrid, Spain.

January 15, 2016 - July 15, 2016: National Distance Education University (UNED), Department of Psychology, Paloma Collado. Madrid, Spain

 

- Gruppo Italiano per lo Studio della Neuromorfologia (G.I.S.N.), from November 2015

 

- Società italiana di neuroscienze (SINS), from May 2017 

 

marraudino.marilena@virgilio.it

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